Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1792632..1793325 Replicon chromosome
Accession NZ_CP069386
Organism Escherichia coli strain XH1815

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSW75_RS08655 Protein ID WP_000415584.1
Coordinates 1793029..1793325 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSW75_RS08650 Protein ID WP_000650107.1
Coordinates 1792632..1793027 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSW75_RS08640 (1788496) 1788496..1790754 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
JSW75_RS08645 (1790892) 1790892..1792499 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JSW75_RS08650 (1792632) 1792632..1793027 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSW75_RS08655 (1793029) 1793029..1793325 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSW75_RS08660 (1793530) 1793530..1794012 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JSW75_RS08665 (1794065) 1794065..1794457 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSW75_RS08670 (1794609) 1794609..1795268 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JSW75_RS08675 (1795265) 1795265..1796614 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JSW75_RS08680 (1796660) 1796660..1796992 - 333 WP_000917684.1 DUF2645 family protein -
JSW75_RS08685 (1797311) 1797311..1797892 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSW75_RS08690 (1797923) 1797923..1798237 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T190310 WP_000415584.1 NZ_CP069386:c1793325-1793029 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T190310 NZ_CP091240:c2720717-2720376 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAGTCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT190310 WP_000650107.1 NZ_CP069386:c1793027-1792632 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT190310 NZ_CP091240:c2720947-2720717 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References