Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4592869..4593471 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag JSR10_RS22310 Protein ID WP_001159630.1
Coordinates 4593160..4593471 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JSR10_RS22305 Protein ID WP_000362050.1
Coordinates 4592869..4593159 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS22290 (4590362) 4590362..4591264 + 903 WP_000331362.1 formate dehydrogenase subunit beta -
JSR10_RS22295 (4591261) 4591261..4591896 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
JSR10_RS22300 (4591893) 4591893..4592822 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
JSR10_RS22305 (4592869) 4592869..4593159 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
JSR10_RS22310 (4593160) 4593160..4593471 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
JSR10_RS22315 (4593689) 4593689..4594618 + 930 WP_001127703.1 alpha/beta hydrolase -
JSR10_RS22320 (4594704) 4594704..4595015 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
JSR10_RS22325 (4595012) 4595012..4595458 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
JSR10_RS22330 (4595473) 4595473..4596414 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
JSR10_RS22335 (4596459) 4596459..4596896 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
JSR10_RS22340 (4596893) 4596893..4597765 - 873 WP_000921427.1 virulence factor BrkB family protein -
JSR10_RS22345 (4597759) 4597759..4598358 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T190286 WP_001159630.1 NZ_CP069381:c4593471-4593160 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T190286 NZ_CP091231:c2787130-2786987 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT190286 WP_000362050.1 NZ_CP069381:c4593159-4592869 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT190286 NZ_CP091231:2786868-2787054 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References