Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2342060..2342582 Replicon chromosome
Accession NZ_CP069381
Organism Salmonella enterica strain GSJ/2016-Sal-016

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag JSR10_RS11350 Protein ID WP_000221343.1
Coordinates 2342298..2342582 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag JSR10_RS11345 Protein ID WP_000885424.1
Coordinates 2342060..2342308 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSR10_RS11325 (2337957) 2337957..2339422 + 1466 Protein_2216 hypothetical protein -
JSR10_RS11330 (2340230) 2340230..2340944 + 715 Protein_2217 helix-turn-helix domain-containing protein -
JSR10_RS11335 (2341000) 2341000..2341659 - 660 Protein_2218 hypothetical protein -
JSR10_RS11340 (2341693) 2341693..2341908 - 216 WP_000206207.1 hypothetical protein -
JSR10_RS11345 (2342060) 2342060..2342308 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JSR10_RS11350 (2342298) 2342298..2342582 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JSR10_RS11355 (2342753) 2342753..2343142 + 390 WP_000194089.1 RidA family protein -
JSR10_RS11360 (2343194) 2343194..2344273 - 1080 WP_023180968.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
JSR10_RS11365 (2344466) 2344466..2344954 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
JSR10_RS11370 (2344999) 2344999..2346507 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2337960..2349364 11404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T190281 WP_000221343.1 NZ_CP069381:2342298-2342582 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T190281 NZ_CP091231:613065-613181 [Enterococcus faecalis]
ATGTTGTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTAGTTTTGCAATACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT190281 WP_000885424.1 NZ_CP069381:2342060-2342308 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT190281 NZ_CP091231:c613297-613092 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTATTGCAAAACTAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References