Detailed information of TA system TA190138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 164002..164513
• Replicon: chromosome
• Accession: NZ_CP069319
• Organism: Kosakonia cowanii strain Pa82

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JMT66_RS00785
• Protein ID: WP_054802690.1
• Coordinates: 164253..164513 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JMT66_RS00780
• Protein ID: WP_232045137.1
• Coordinates: 164002..164256 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMT66_RS00760 (JMT66_00760)	160506..160952	-	447	WP_042718597.1	N-acetyltransferase	-
JMT66_RS00765 (JMT66_00765)	160930..161511	-	582	WP_200580324.1	DNA-3-methyladenine glycosylase I	-
JMT66_RS00770 (JMT66_00770)	161659..162339	+	681	WP_094418958.1	autotransporter domain-containing protein	-
JMT66_RS00775 (JMT66_00775)	162581..163783	+	1203	WP_076769346.1	MFS transporter	-
JMT66_RS00780 (JMT66_00780)	164002..164256	+	255	WP_232045137.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMT66_RS00785 (JMT66_00785)	164253..164513	+	261	WP_054802690.1	Txe/YoeB family addiction module toxin	Toxin
JMT66_RS00790 (JMT66_00790)	164617..165048	+	432	WP_042718589.1	organic hydroperoxide resistance protein	-
JMT66_RS00795 (JMT66_00795)	165263..166945	+	1683	WP_200580325.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-76)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10250.87 Da
• Isoelectric Point: 9.7713

>T190138 WP_054802690.1 NZ_CP069319:164253-164513 [Kosakonia cowanii]
MTPRITPEAQADIDFWKQNDPKVKQKIDTLVRDALEHPFQGLGKPEALKHHKPLWSRRITKEHRLVYYIKDDSLIIVSCR
YHYVNL

Nucleotide

• Length: 261 bp

>T190138 NZ_CP091121:4099298-4099642 [Serratia ureilytica]
ATGTGGCAAGTGGTGACCGTCGAACGATTCGACGACTGGTTTTTGGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAGTTGGCGCGGCCGCACGCCGATACGCTGCATTTTTCCGAAGCGGCCC
GGCAGTTGAAGGAGTTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCA
GTATTGCTGTGCGGTGGCGATAAAACCAGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCTGCCATGGAATTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9462.58 Da
• Isoelectric Point: 4.5298

>AT190138 WP_232045137.1 NZ_CP069319:164002-164256 [Kosakonia cowanii]
MNMQHVNYTDARQNLASLMQQANDELAPILVTRKGAKSVVVIDAEEFASMQETLHLFSNPVNAAHIERSIQQAESGDLQE
YKFE

Nucleotide

• Length: 255 bp

>AT190138 NZ_CP091121:4099648-4099950 [Serratia ureilytica]
ATGGCCAAACCGTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCGCAGCCAGGCAAAAGGCGGACAAGGA
AATTTTCGAACTGCGGCTGGCAATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGTATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA