190137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 48704..49411 Replicon chromosome
Accession NZ_CP069319
Organism Kosakonia cowanii strain Pa82

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JMT66_RS00240 Protein ID WP_076769309.1
Coordinates 49106..49411 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag JMT66_RS00235 Protein ID WP_200580279.1
Coordinates 48704..49105 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMT66_RS00215 (JMT66_00220) 44481..45428 + 948 WP_200580329.1 ABC transporter permease -
JMT66_RS00220 (JMT66_00225) 45425..46408 + 984 WP_042715059.1 ABC transporter ATP-binding protein -
JMT66_RS00225 (JMT66_00230) 46405..47379 + 975 WP_200580278.1 ATP-binding cassette domain-containing protein -
JMT66_RS00230 (JMT66_00235) 47453..48646 + 1194 WP_042715056.1 zinc-dependent alcohol dehydrogenase -
JMT66_RS00235 (JMT66_00240) 48704..49105 - 402 WP_200580279.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMT66_RS00240 (JMT66_00245) 49106..49411 - 306 WP_076769309.1 type II toxin-antitoxin system MqsR family toxin Toxin
JMT66_RS00245 (JMT66_00250) 49569..50222 - 654 WP_042715053.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
JMT66_RS00250 (JMT66_00255) 50417..51352 + 936 WP_200580330.1 LysR family transcriptional regulator -
JMT66_RS00255 (JMT66_00260) 51414..52367 + 954 WP_128481852.1 aldo/keto reductase -
JMT66_RS00260 (JMT66_00265) 52474..53646 - 1173 WP_200580280.1 multidrug effflux MFS transporter -
JMT66_RS00265 (JMT66_00270) 53754..54356 - 603 WP_200580281.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11603.59 Da        Isoelectric Point: 8.9492

>T190137 WP_076769309.1 NZ_CP069319:c49411-49106 [Kosakonia cowanii]
MEKGTPHVRLHIVKRMVLEGKVRTTASAVAGAIELGFNPPPFDEMCAVIQALTSEDFFKSMTAYVDHTVWHDVYRPVWKR
QKLYLKLIVSDDVLIVSFKER

Download         Length: 306 bp

>T190137 NZ_CP091121:c3370719-3370366 [Serratia ureilytica]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCGCTCAGCGATGCCGATCGGGCCGGTGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGGCGGGGCTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14939.17 Da        Isoelectric Point: 8.4823

>AT190137 WP_200580279.1 NZ_CP069319:c49105-48704 [Kosakonia cowanii]
MKCPVCGAAGLKHDTRNIEYRYKGKVTTLTAITGDYCDACGEIIFDRLNGELYSKQVAAFVRKVNAEEVDPQFIATIRKR
FNLDQRQAAEMFGGGANAFSRYETGRVAPPRPLVLLFKALDKHPELFEELKHA

Download         Length: 402 bp

>AT190137 NZ_CP091121:c3370361-3370059 [Serratia ureilytica]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References