Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6184614..6185288 Replicon chromosome
Accession NZ_CP069318
Organism Delftia lacustris strain R54

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag JQN63_RS28300 Protein ID WP_043789322.1
Coordinates 6184614..6184895 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag JQN63_RS28305 Protein ID WP_012203141.1
Coordinates 6184977..6185288 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN63_RS28280 6180310..6180876 - 567 WP_043789355.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
JQN63_RS28285 6180882..6181910 - 1029 WP_203400011.1 type I-F CRISPR-associated protein Csy3 -
JQN63_RS28290 6181965..6183053 - 1089 WP_203400012.1 type I-F CRISPR-associated protein Csy2 -
JQN63_RS28295 6183050..6184447 - 1398 WP_203401071.1 type I-F CRISPR-associated protein Csy1 -
JQN63_RS28300 6184614..6184895 + 282 WP_043789322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQN63_RS28305 6184977..6185288 + 312 WP_012203141.1 HigA family addiction module antidote protein Antitoxin
JQN63_RS28310 6185292..6188780 - 3489 WP_203400013.1 type I-F CRISPR-associated helicase Cas3 -
JQN63_RS28315 6188777..6189799 - 1023 WP_203400014.1 type I-F CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.30 Da        Isoelectric Point: 8.5442

>T190135 WP_043789322.1 NZ_CP069318:6184614-6184895 [Delftia lacustris]
MAITSFKCPETQRLFTSGKTRRFANIQSVAERKLAQLDAAVTLEFLRSPPGNRLEMLVGDRQGQHSIRINDQWRLCFVWT
EKGVVDVEIVDYH

Download         Length: 282 bp

>T190135 NZ_CP091121:1598917-1599225 [Serratia ureilytica]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCTACCCGGTTAGTGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AAATTGAGATCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11615.32 Da        Isoelectric Point: 8.6927

>AT190135 WP_012203141.1 NZ_CP069318:6184977-6185288 [Delftia lacustris]
MLKNGMRPIHPGEVLREDYLKPMDMSANALARHLHVPASRVNDIVLERRGITADTALRLSRFFGGDAQSWLNLQTAYDLR
TAELNAELQASVRQVHPMQLHTA

Download         Length: 312 bp

>AT190135 NZ_CP091121:1598678-1598914 [Serratia ureilytica]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGTGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References