Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3587978..3588571 Replicon chromosome
Accession NZ_CP069318
Organism Delftia lacustris strain R54

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JQN63_RS16495 Protein ID WP_047218636.1
Coordinates 3588293..3588571 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JQN63_RS16490 Protein ID WP_043791964.1
Coordinates 3587978..3588280 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN63_RS16470 3583790..3585055 + 1266 WP_203399397.1 serine hydroxymethyltransferase -
JQN63_RS16475 3585148..3586200 - 1053 WP_203399398.1 hypothetical protein -
JQN63_RS16480 3586197..3586670 - 474 WP_050042469.1 hypothetical protein -
JQN63_RS16485 3586822..3587862 - 1041 WP_203399399.1 patatin-like phospholipase family protein -
JQN63_RS16490 3587978..3588280 - 303 WP_043791964.1 HigA family addiction module antidote protein Antitoxin
JQN63_RS16495 3588293..3588571 - 279 WP_047218636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQN63_RS16500 3588638..3589540 - 903 WP_203399400.1 LysR family transcriptional regulator -
JQN63_RS16505 3589555..3590091 - 537 WP_034367535.1 MarR family winged helix-turn-helix transcriptional regulator -
JQN63_RS16510 3590296..3591504 + 1209 WP_203399401.1 3-hydroxybenzoate 6-monooxygenase -
JQN63_RS16515 3591521..3592558 + 1038 WP_203399402.1 cupin domain-containing protein -
JQN63_RS16520 3592627..3593301 + 675 Protein_3251 fumarylacetoacetate hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10546.22 Da        Isoelectric Point: 9.2618

>T190134 WP_047218636.1 NZ_CP069318:c3588571-3588293 [Delftia lacustris]
MILDFRCADTQALMLGKRVARFANLEVAAMRKLVQLNAATSLEFLRIPPGNRLEALQGSRRGQYSIRINEQWRLCFVWAD
GHASQVEIVDYH

Download         Length: 279 bp

>T190134 NZ_CP091121:c1108096-1107893 [Serratia ureilytica]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAAAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCCGCCGATCATCGTTTGGCGGAGCTGACCATGAACAAGC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11378.09 Da        Isoelectric Point: 5.1007

>AT190134 WP_043791964.1 NZ_CP069318:c3588280-3587978 [Delftia lacustris]
MTREVKWPHPGEILMQEWLEPMGLSQYALAKAIDVPPRRINEIVKGMRGITADTALRLAVFFGTDAQSWLNLQSDYDLAE
ARDAMADVLARIQRFEPTHP

Download         Length: 303 bp

>AT190134 NZ_CP091121:c1108515-1108147 [Serratia ureilytica]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAACTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACCCTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTTCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCCGATTTGTCGGAGTTAGTCGAGGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References