Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 915435..916042 Replicon chromosome
Accession NZ_CP069308
Organism Glaesserella parasuis strain EHP1804

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JQC68_RS04800 Protein ID WP_021109713.1
Coordinates 915435..915779 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JQC68_RS04805 Protein ID WP_203399279.1
Coordinates 915782..916042 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQC68_RS04785 911260..911856 + 597 WP_075604519.1 DedA family protein -
JQC68_RS04790 912039..913130 - 1092 WP_005714201.1 murein transglycosylase A -
JQC68_RS04795 913241..915220 - 1980 WP_203399278.1 exoribonuclease II -
JQC68_RS04800 915435..915779 + 345 WP_021109713.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JQC68_RS04805 915782..916042 + 261 WP_203399279.1 helix-turn-helix domain-containing protein Antitoxin
JQC68_RS04810 916057..917265 - 1209 WP_016527735.1 IS256 family transposase -
JQC68_RS04815 917571..918779 + 1209 WP_016527735.1 IS256 family transposase -
JQC68_RS04820 918850..919914 - 1065 WP_071610276.1 DUF3944 domain-containing protein -
JQC68_RS04825 920061..920483 + 423 WP_043894462.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-75)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13262.28 Da        Isoelectric Point: 7.9640

>T190123 WP_021109713.1 NZ_CP069308:915435-915779 [Glaesserella parasuis]
METEEYLTFIKTKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T190123 NZ_CP091120:c1086051-1085848 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9821.34 Da        Isoelectric Point: 8.8639

>AT190123 WP_203399279.1 NZ_CP069308:915782-916042 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARD
PIPNSV

Download         Length: 261 bp

>AT190123 NZ_CP091120:c1086470-1086102 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GATGATACCTATACGCTGTTCAGCAGTTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References