190119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1322933..1323456 Replicon chromosome
Accession NZ_CP069306
Organism Rhodococcus aetherivorans isolate PSBB011

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0M8PPF9
Locus tag JQ505_RS06195 Protein ID WP_054372088.1
Coordinates 1323196..1323456 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M8PPH9
Locus tag JQ505_RS06190 Protein ID WP_003934441.1
Coordinates 1322933..1323193 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQ505_RS06165 1319072..1319704 - 633 WP_185713181.1 ribulose 1,5-bisphosphate carboxylase large subunit -
JQ505_RS06170 1320016..1320474 + 459 WP_185713180.1 hypothetical protein -
JQ505_RS06175 1320570..1321040 - 471 WP_185713179.1 IS200/IS605 family transposase -
JQ505_RS06180 1321066..1322259 + 1194 WP_203329832.1 transposase -
JQ505_RS06185 1322303..1322656 - 354 WP_185713177.1 hypothetical protein -
JQ505_RS06190 1322933..1323193 + 261 WP_003934441.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JQ505_RS06195 1323196..1323456 + 261 WP_054372088.1 Txe/YoeB family addiction module toxin Toxin
JQ505_RS06200 1323590..1325209 + 1620 WP_203329833.1 alpha/beta fold hydrolase -
JQ505_RS06205 1325958..1327211 + 1254 WP_203329834.1 hypothetical protein -
JQ505_RS06210 1327255..1328061 + 807 WP_185713174.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1314182..1323456 9274


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10440.85 Da        Isoelectric Point: 9.4584

>T190119 WP_054372088.1 NZ_CP069306:1323196-1323456 [Rhodococcus aetherivorans]
VRLVWDVNAWEDYLWWQTQDRKVLRRINALVQDILRNGNEGIGKPEPLKHDFAGYWSRRITDEHRLVYKITDTEVRIAAC
RYHYGR

Download         Length: 261 bp

>T190119 NZ_CP091100:2333333-2333674 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9753.89 Da        Isoelectric Point: 4.3529

>AT190119 WP_003934441.1 NZ_CP069306:1322933-1323193 [Rhodococcus aetherivorans]
MRTMSYSESRARYAEVLDSVVNDREEIVITRSGHEPVVIVSLADFESLRETAYLMRSPANARRLLDAMERLEAGEGQVHE
LIEGDD

Download         Length: 261 bp

>AT190119 NZ_CP091100:2333103-2333333 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M8PPF9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M8PPH9

References