Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 33780..34430 Replicon chromosome
Accession NZ_CP069159
Organism Citrobacter sp. R56

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JM656_RS00165 Protein ID WP_203359536.1
Coordinates 33780..34121 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JM656_RS00170 Protein ID WP_203359537.1
Coordinates 34131..34430 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM656_RS00150 29701..31464 - 1764 WP_203359533.1 adenine deaminase -
JM656_RS00155 31641..32975 + 1335 WP_203359534.1 NCS2 family permease -
JM656_RS00160 33028..33480 + 453 WP_203359535.1 DUF1198 domain-containing protein -
JM656_RS00165 33780..34121 + 342 WP_203359536.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JM656_RS00170 34131..34430 + 300 WP_203359537.1 helix-turn-helix transcriptional regulator Antitoxin
JM656_RS00175 34551..35747 + 1197 WP_203359538.1 purine ribonucleoside efflux pump NepI -
JM656_RS00180 35781..37163 - 1383 WP_203359539.1 glycoside hydrolase family 1 protein -
JM656_RS00185 37292..37585 - 294 WP_203359540.1 hypothetical protein -
JM656_RS00190 37714..38130 + 417 WP_203359541.1 GNAT family N-acetyltransferase -
JM656_RS00195 38296..39114 + 819 WP_203359542.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13105.85 Da        Isoelectric Point: 5.1962

>T189993 WP_203359536.1 NZ_CP069159:33780-34121 [Citrobacter sp. R56]
MWDVETTDVFDRWFDEQTEALKEDILAAMIILSEYGPQLGRPFADTVNDSAFSNMKELRIQHQGNPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKDMIKFADAEYRKHLNK

Download         Length: 342 bp

>T189993 NZ_CP091050:c77342-76860 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10886.72 Da        Isoelectric Point: 7.2046

>AT189993 WP_203359537.1 NZ_CP069159:34131-34430 [Citrobacter sp. R56]
MATLKELMAKQTPESQARIAEKVEEMHQAIALSMLREELNLSQAELAAAMGVKQPTIAKMEQAENDPRLSTLKRYVAALG
GELSIDVKLPTGKRVAFHI

Download         Length: 300 bp

>AT189993 NZ_CP091050:c77611-77333 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References