Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2288297..2288955 Replicon chromosome
Accession NZ_CP069157
Organism Morganella morganii strain DSM 30164

Toxin (Protein)


Gene name higB Uniprot ID A0A447J593
Locus tag JL661_RS11130 Protein ID WP_032098584.1
Coordinates 2288602..2288955 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag JL661_RS11125 Protein ID WP_004236876.1
Coordinates 2288297..2288599 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL661_RS11085 (JL661_11085) 2284663..2285358 - 696 WP_004240015.1 MgtC family protein -
JL661_RS11090 (JL661_11090) 2285708..2285902 - 195 WP_015422621.1 protein DsrB -
JL661_RS11095 (JL661_11095) 2286006..2286218 - 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JL661_RS11100 (JL661_11100) 2286679..2287188 + 510 WP_004240013.1 YlaC family protein -
JL661_RS11125 (JL661_11125) 2288297..2288599 - 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
JL661_RS11130 (JL661_11130) 2288602..2288955 - 354 WP_032098584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JL661_RS11135 (JL661_11135) 2289232..2290284 + 1053 WP_062772495.1 dihydroorotase -
JL661_RS11140 (JL661_11140) 2290519..2290776 + 258 WP_004236879.1 biofilm formation regulator BssS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.58 Da        Isoelectric Point: 9.9631

>T189991 WP_032098584.1 NZ_CP069157:c2288955-2288602 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T189991 NZ_CP091048:c5167163-5166780 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT189991 WP_004236876.1 NZ_CP069157:c2288599-2288297 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT189991 NZ_CP091048:c5167405-5167163 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447J593

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References