Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2962669..2963317 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN136_RS13980 Protein ID WP_003899414.1
Coordinates 2962669..2962992 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN136_RS13985 Protein ID WP_003899415.1
Coordinates 2963072..2963317 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS13950 2957992..2958990 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN136_RS13955 2959004..2959468 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN136_RS13960 2959456..2959707 + 252 WP_003908028.1 hypothetical protein -
JN136_RS13965 2959878..2961317 - 1440 WP_003901443.1 phage major capsid protein -
JN136_RS13970 2961325..2961858 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN136_RS13975 2962011..2962502 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN136_RS13980 2962669..2962992 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN136_RS13985 2963072..2963317 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN136_RS13990 2963314..2964741 - 1428 WP_003901445.1 DUF3631 domain-containing protein -
JN136_RS13995 2964743..2965135 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN136_RS14000 2965132..2965392 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN136_RS14005 2965409..2965771 - 363 WP_003900543.1 hypothetical protein -
JN136_RS14010 2965774..2966901 - 1128 WP_003899420.1 site-specific integrase -
JN136_RS14015 2967046..2967273 - 228 WP_003899421.1 hypothetical protein -
JN136_RS14020 2967270..2967659 - 390 WP_003899422.1 hypothetical protein -
JN136_RS14025 2967565..2967837 + 273 WP_003900544.1 hypothetical protein -
JN136_RS14030 2967936..2968169 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2957992..2966901 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189750 WP_003899414.1 NZ_CP069076:c2962992-2962669 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189750 NZ_CP090968:1741910-1742011 [Edwardsiella piscicida]
GCAAGGCACTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCAAAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGTTAGGTCTTTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189750 WP_003899415.1 NZ_CP069076:c2963317-2963072 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189750 NZ_CP090968:c1742013-1741903 [Edwardsiella piscicida]
ATAAAAAAAGACCTAACACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTTTGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAGTGCCTTGCTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References