Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2259879..2260798 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JN136_RS10630 Protein ID WP_003901311.1
Coordinates 2260193..2260798 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag JN136_RS10625 Protein ID WP_003410124.1
Coordinates 2259879..2260184 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS10595 2254890..2256146 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
JN136_RS10600 2256500..2257075 + 576 WP_003410100.1 hypothetical protein -
JN136_RS10605 2257072..2258112 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
JN136_RS10610 2258354..2259073 + 720 WP_003410108.1 DUF433 domain-containing protein -
JN136_RS10615 2259063..2259479 + 417 WP_003410114.1 hypothetical protein -
JN136_RS10620 2259495..2259794 - 300 WP_003410120.1 hypothetical protein -
JN136_RS10625 2259879..2260184 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
JN136_RS10630 2260193..2260798 - 606 WP_003901311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN136_RS10635 2260823..2261182 - 360 WP_003410131.1 hypothetical protein -
JN136_RS10640 2261342..2261932 - 591 WP_235678788.1 hypothetical protein -
JN136_RS10645 2261971..2262207 - 237 WP_003410133.1 hypothetical protein -
JN136_RS10650 2262414..2263310 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22777.02 Da        Isoelectric Point: 7.3073

>T189740 WP_003901311.1 NZ_CP069076:c2260798-2260193 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCMISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T189740 NZ_CP090964:c12302-12015 [Edwardsiella piscicida]
ATGACATATCGGGTAAAGTTTAGATCGGATGCATTGAAAGAGTGGAATAACCTTGATAAGGCTATTCAGCAGCAGTTCGC
CAGAAAGCTCAAGAAGTGTGCCGAAAATCCTCATAACCCCTCCGCGAGGCTTCGAGGGATGCCTAATTGTTATAAGATAA
AATTACGGGCATCTGGCTTTAGGTTGGTTTATCAGGTTATTAATGACGAGTTAATTATTGCTGTGGTCGCCGTGGGTAAA
CGGGAGCGCAGTGAGGTATACACGCTAGCCAGCAAACGGCTCAGATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT189740 WP_003410124.1 NZ_CP069076:c2260184-2259879 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT189740 NZ_CP090964:c12550-12299 [Edwardsiella piscicida]
ATGCCCAACATCATTCATAGTGATACCACAGCTAGTGTCAGTGAGCTTAAGAAAAACCCAATGGCTACCGTCAATTCTGG
TGCAGGCTTTCCTGTGGCAATTTTGAACCACAACCAGCCGGTTTTCTACTGCATACCAGCCGAACTCTATGAACAAATGC
TTGACTACATTGATGATCAGGAGCTGTCTAAACAGGTTCAGAAACGCAGTAAGCAGACCTTACACGATGTAGATCTGGAT
AGCTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References