Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2982350..2982998 Replicon chromosome
Accession NZ_CP069075
Organism Mycobacterium tuberculosis strain N0004

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN138_RS14090 Protein ID WP_003899414.1
Coordinates 2982350..2982673 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN138_RS14095 Protein ID WP_003899415.1
Coordinates 2982753..2982998 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN138_RS14060 2977673..2978671 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN138_RS14065 2978685..2979149 + 465 WP_244694657.1 hypothetical protein -
JN138_RS14070 2979137..2979388 + 252 WP_003908028.1 hypothetical protein -
JN138_RS14075 2979559..2980998 - 1440 WP_003901443.1 phage major capsid protein -
JN138_RS14080 2981006..2981539 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN138_RS14085 2981692..2982183 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN138_RS14090 2982350..2982673 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN138_RS14095 2982753..2982998 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN138_RS14100 2982995..2984422 - 1428 WP_244694659.1 DUF3631 domain-containing protein -
JN138_RS14105 2984424..2984816 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN138_RS14110 2984813..2985073 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN138_RS14115 2985090..2985452 - 363 WP_003900543.1 hypothetical protein -
JN138_RS14120 2985455..2986582 - 1128 WP_003899420.1 site-specific integrase -
JN138_RS14125 2986727..2986954 - 228 WP_003899421.1 hypothetical protein -
JN138_RS14130 2986951..2987340 - 390 WP_003899422.1 hypothetical protein -
JN138_RS14135 2987246..2987518 + 273 WP_003900544.1 hypothetical protein -
JN138_RS14140 2987617..2987850 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2977673..2986582 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189689 WP_003899414.1 NZ_CP069075:c2982673-2982350 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189689 NZ_CP090930:210108-210593 [Salmonella enterica subsp. enterica serovar Agona]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTTGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189689 WP_003899415.1 NZ_CP069075:c2982998-2982753 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189689 NZ_CP090930:209833-210120 [Salmonella enterica subsp. enterica serovar Agona]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTATATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References