189629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3001151..3001799 Replicon chromosome
Accession NZ_CP069074
Organism Mycobacterium tuberculosis strain N1274

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN139_RS14170 Protein ID WP_003899414.1
Coordinates 3001151..3001474 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN139_RS14175 Protein ID WP_003899415.1
Coordinates 3001554..3001799 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN139_RS14140 2996475..2997473 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN139_RS14145 2997487..2997951 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN139_RS14150 2997939..2998190 + 252 WP_003908028.1 hypothetical protein -
JN139_RS14155 2998361..2999800 - 1440 WP_003901443.1 phage major capsid protein -
JN139_RS14160 2999808..3000340 - 533 Protein_2792 HK97 family phage prohead protease -
JN139_RS14165 3000493..3000984 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN139_RS14170 3001151..3001474 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN139_RS14175 3001554..3001799 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN139_RS14180 3001796..3003223 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JN139_RS14185 3003225..3003617 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN139_RS14190 3003614..3003874 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN139_RS14195 3003891..3004253 - 363 WP_003900543.1 hypothetical protein -
JN139_RS14200 3004256..3005383 - 1128 WP_003899420.1 site-specific integrase -
JN139_RS14205 3005528..3005755 - 228 WP_003899421.1 hypothetical protein -
JN139_RS14210 3005752..3006141 - 390 WP_003899422.1 hypothetical protein -
JN139_RS14215 3006047..3006319 + 273 WP_003900544.1 hypothetical protein -
JN139_RS14220 3006418..3006651 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2996475..3005383 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189629 WP_003899414.1 NZ_CP069074:c3001474-3001151 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189629 NZ_CP090908:c14482-14102 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATTCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTTT
GACCGAATACCACACCAATCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAGCAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189629 WP_003899415.1 NZ_CP069074:c3001799-3001554 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189629 NZ_CP090908:c14703-14482 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGCTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References