Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2986792..2987440 Replicon chromosome
Accession NZ_CP069073
Organism Mycobacterium tuberculosis strain N0054

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN140_RS14120 Protein ID WP_003899414.1
Coordinates 2986792..2987115 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN140_RS14125 Protein ID WP_003899415.1
Coordinates 2987195..2987440 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN140_RS14090 2982115..2983113 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN140_RS14095 2983127..2983591 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN140_RS14100 2983579..2983830 + 252 WP_003908028.1 hypothetical protein -
JN140_RS14105 2984001..2985440 - 1440 WP_003901443.1 phage major capsid protein -
JN140_RS14110 2985448..2985981 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN140_RS14115 2986134..2986625 - 492 WP_079015664.1 phage terminase small subunit P27 family -
JN140_RS14120 2986792..2987115 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN140_RS14125 2987195..2987440 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN140_RS14130 2987437..2988864 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JN140_RS14135 2988866..2989258 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN140_RS14140 2989255..2989515 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN140_RS14145 2989532..2989894 - 363 WP_003900543.1 hypothetical protein -
JN140_RS14150 2989897..2991024 - 1128 WP_003899420.1 site-specific integrase -
JN140_RS14155 2991169..2991396 - 228 WP_003899421.1 hypothetical protein -
JN140_RS14160 2991393..2991782 - 390 WP_003899422.1 hypothetical protein -
JN140_RS14165 2991688..2991960 + 273 WP_003900544.1 hypothetical protein -
JN140_RS14170 2992059..2992292 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2982115..2991024 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189568 WP_003899414.1 NZ_CP069073:c2987115-2986792 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189568 NZ_CP090877:1693057-1693164 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189568 WP_003899415.1 NZ_CP069073:c2987440-2987195 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189568 NZ_CP090877:c1693241-1693181 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References