Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2201208..2202076 | Replicon | chromosome |
| Accession | NZ_CP069073 | ||
| Organism | Mycobacterium tuberculosis strain N0054 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JN140_RS10310 | Protein ID | WP_010886136.1 |
| Coordinates | 2201208..2201585 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | JN140_RS10315 | Protein ID | WP_003409886.1 |
| Coordinates | 2201627..2202076 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN140_RS10260 | 2196998..2197449 | - | 452 | Protein_2025 | hypothetical protein | - |
| JN140_RS10265 | 2197513..2197914 | + | 402 | WP_244750305.1 | hypothetical protein | - |
| JN140_RS10270 | 2197907..2198089 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JN140_RS10275 | 2198203..2198553 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JN140_RS10280 | 2198564..2199466 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JN140_RS10285 | 2199487..2199678 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN140_RS10290 | 2199679..2199975 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN140_RS10295 | 2200215..2200430 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN140_RS10300 | 2200427..2200738 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN140_RS10305 | 2200712..2201233 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN140_RS10310 | 2201208..2201585 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JN140_RS10315 | 2201627..2202076 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| JN140_RS10320 | 2202073..2202618 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN140_RS10325 | 2202507..2203121 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN140_RS10330 | 2203170..2203466 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JN140_RS10335 | 2203463..2203714 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JN140_RS10340 | 2203701..2204195 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN140_RS10345 | 2204355..2204762 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN140_RS10350 | 2204766..2205038 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN140_RS10355 | 2205071..2206291 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T189552 WP_010886136.1 NZ_CP069073:2201208-2201585 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T189552 NZ_CP090873:1587854-1588030 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT189552 WP_003409886.1 NZ_CP069073:2201627-2202076 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT189552 NZ_CP090873:c1588192-1588018 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|