Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2969111..2969759 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN142_RS14005 Protein ID WP_003899414.1
Coordinates 2969111..2969434 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN142_RS14010 Protein ID WP_003899415.1
Coordinates 2969514..2969759 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS13975 2964434..2965432 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN142_RS13980 2965446..2965910 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN142_RS13985 2965898..2966149 + 252 WP_003908028.1 hypothetical protein -
JN142_RS13990 2966320..2967759 - 1440 WP_003899411.1 phage major capsid protein -
JN142_RS13995 2967767..2968300 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN142_RS14000 2968453..2968944 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN142_RS14005 2969111..2969434 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN142_RS14010 2969514..2969759 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN142_RS14015 2969756..2971183 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JN142_RS14020 2971185..2971577 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN142_RS14025 2971574..2971834 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN142_RS14030 2971851..2972213 - 363 WP_003900543.1 hypothetical protein -
JN142_RS14035 2972216..2973343 - 1128 WP_003899420.1 site-specific integrase -
JN142_RS14040 2973488..2973715 - 228 WP_003899421.1 hypothetical protein -
JN142_RS14045 2973712..2974101 - 390 WP_003899422.1 hypothetical protein -
JN142_RS14050 2974007..2974279 + 273 WP_003900544.1 hypothetical protein -
JN142_RS14055 2974378..2974611 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2964434..2973343 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189447 WP_003899414.1 NZ_CP069071:c2969434-2969111 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189447 NZ_CP090770:c3295063-3294662 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGCTATGCACCAATC
CTGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGTTGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189447 WP_003899415.1 NZ_CP069071:c2969759-2969514 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189447 NZ_CP090770:c3295299-3295063 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References