189431

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2193549..2194417 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag JN142_RS10240 Protein ID WP_010886136.1
Coordinates 2193549..2193926 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag JN142_RS10245 Protein ID WP_003409886.1
Coordinates 2193968..2194417 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS10190 2189338..2189790 - 453 WP_003899095.1 lipoprotein -
JN142_RS10195 2189854..2190255 + 402 WP_003409869.1 hypothetical protein -
JN142_RS10200 2190248..2190430 - 183 WP_003409870.1 hypothetical protein -
JN142_RS10205 2190544..2190894 - 351 WP_003899096.1 hypothetical protein -
JN142_RS10210 2190905..2191807 - 903 WP_003899097.1 hypothetical protein -
JN142_RS10215 2191828..2192019 - 192 WP_003409876.1 hypothetical protein -
JN142_RS10220 2192020..2192316 - 297 WP_003409877.1 hypothetical protein -
JN142_RS10225 2192556..2192771 + 216 WP_003409878.1 antitoxin -
JN142_RS10230 2192768..2193079 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN142_RS10235 2193053..2193574 - 522 WP_003904745.1 hypothetical protein -
JN142_RS10240 2193549..2193926 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
JN142_RS10245 2193968..2194417 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JN142_RS10250 2194414..2194959 + 546 WP_003409891.1 SecB-like chaperone -
JN142_RS10255 2194848..2195462 - 615 WP_003901296.1 hypothetical protein -
JN142_RS10260 2195511..2195807 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
JN142_RS10265 2195804..2196055 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
JN142_RS10270 2196042..2196536 + 495 WP_003899099.1 hypothetical protein -
JN142_RS10275 2196696..2197103 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN142_RS10280 2197107..2197379 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN142_RS10285 2197412..2198632 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T189431 WP_010886136.1 NZ_CP069071:2193549-2193926 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T189431 NZ_CP090765:906953-907849 [Burkholderia multivorans]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGGCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGTGCGGCAGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCATGCCGGCGCCGCGCTGGCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCATCGCCGTCGGCCGTCGATTACGCGGCGTCGCTCGACGC
CTGGCTCGATGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGGATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGTGCGCCGGCCGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAAGACGCGCGCGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCGGCCGATCTCGCCGGGTTTCGCGGCCGCACGGCGGTGGCCGTCGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGTGAGCGAATCGCGGCGGCGGCCGGCGTCGGACTGCAGGTGATTCCGCA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCCGACGTCTATTCGGCCTTGATCGACACGTTCTGCCGGCAGTGCGACATCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT189431 WP_003409886.1 NZ_CP069071:2193968-2194417 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT189431 NZ_CP090765:907846-908700 [Burkholderia multivorans]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAACCCGCGAAGGCCGAAGCGAGCTACGTCGTGCCGGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCTCTGGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCCAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTCTCGCTGGACGAGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGATGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGGATTTCGGTCGTCACCGCGCCGGTACGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGATGGGCTGATCGACAAGGTGCGGCGTGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAGCACACCTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References