Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2984919..2985567 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag JN143_RS14040 Protein ID WP_003899414.1
Coordinates 2984919..2985242 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN143_RS14045 Protein ID WP_003899415.1
Coordinates 2985322..2985567 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS14010 2980242..2981240 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
JN143_RS14015 2981254..2981718 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN143_RS14020 2981706..2981957 + 252 WP_003908028.1 hypothetical protein -
JN143_RS14025 2982128..2983567 - 1440 WP_031714268.1 phage major capsid protein -
JN143_RS14030 2983575..2984108 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN143_RS14035 2984261..2984752 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN143_RS14040 2984919..2985242 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
JN143_RS14045 2985322..2985567 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN143_RS14050 2985564..2986990 - 1427 Protein_2772 DUF3631 domain-containing protein -
JN143_RS14055 2986992..2987384 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN143_RS14060 2987381..2987641 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN143_RS14065 2987658..2988020 - 363 WP_003900543.1 hypothetical protein -
JN143_RS14070 2988023..2989150 - 1128 WP_003899420.1 site-specific integrase -
JN143_RS14075 2989295..2989522 - 228 WP_003899421.1 hypothetical protein -
JN143_RS14080 2989519..2989908 - 390 WP_003899422.1 hypothetical protein -
JN143_RS14085 2989814..2990086 + 273 WP_003900544.1 hypothetical protein -
JN143_RS14090 2990185..2990418 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2980242..2989150 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T189386 WP_003899414.1 NZ_CP069070:c2985242-2984919 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T189386 NZ_CP090748:1685001-1685579 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCACGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGCCCGAGCAAGCCGCGCATCCGGACAAGAACATGCACGAACGCGACGACCTGCTCACACTGACGGCCGCACGCGATCC
CGTGCTGCGTAACGAGCTCGTCGCACTGTGGGACGAATACGACGTGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGACTAC
GGCCGGCGCTATACGGATGCGGCACCGCTGTTCAGCGCGATCCGCGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACACACGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189386 WP_003899415.1 NZ_CP069070:c2985567-2985322 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189386 NZ_CP090748:1684309-1684866 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTGGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTCGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAAATCGTCCGGATGGAAAGCGCACTGG
GCACACTCGGCTGGCACGATTGCGCAGGACCGCCTAGCGTCGAATTCGACACCGGCACGAACGCGTCGCGCGTCGTGCCG
ATCCATCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGATCGGCGGCACGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References