Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/- |
| Location | 2988394..2989063 | Replicon | chromosome |
| Accession | NZ_CP069069 | ||
| Organism | Mycobacterium tuberculosis strain N1176 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | - |
| Locus tag | JN144_RS14105 | Protein ID | WP_244732544.1 |
| Coordinates | 2988394..2988738 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
| Locus tag | JN144_RS14110 | Protein ID | WP_003899415.1 |
| Coordinates | 2988818..2989063 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN144_RS14075 | 2983738..2984736 | + | 999 | WP_003908027.1 | tyrosine-type recombinase/integrase | - |
| JN144_RS14080 | 2984750..2985214 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
| JN144_RS14085 | 2985202..2985453 | + | 252 | WP_003908028.1 | hypothetical protein | - |
| JN144_RS14090 | 2985624..2987063 | - | 1440 | WP_003901443.1 | phage major capsid protein | - |
| JN144_RS14095 | 2987071..2987604 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
| JN144_RS14100 | 2987757..2988248 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
| JN144_RS14105 | 2988394..2988738 | - | 345 | WP_244732544.1 | type II toxin-antitoxin system toxin | Toxin |
| JN144_RS14110 | 2988818..2989063 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| JN144_RS14115 | 2989060..2990487 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
| JN144_RS14120 | 2990489..2990881 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
| JN144_RS14125 | 2990878..2991138 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
| JN144_RS14130 | 2991155..2991517 | - | 363 | WP_003900543.1 | hypothetical protein | - |
| JN144_RS14135 | 2991520..2992647 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
| JN144_RS14140 | 2992792..2993019 | - | 228 | WP_003909716.1 | hypothetical protein | - |
| JN144_RS14145 | 2993016..2993405 | - | 390 | WP_003899422.1 | hypothetical protein | - |
| JN144_RS14150 | 2993311..2993583 | + | 273 | WP_003900544.1 | hypothetical protein | - |
| JN144_RS14155 | 2993682..2993915 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2983738..2992647 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13285.99 Da Isoelectric Point: 10.8001
>T189325 WP_244732544.1 NZ_CP069069:c2988738-2988394 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQRKPKIRR
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQRKPKIRR
Download Length: 345 bp
>T189325 NZ_CP090732:c1694530-1694234 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGTCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAACTCGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGTCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAACTCGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT189325 WP_003899415.1 NZ_CP069069:c2989063-2988818 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT189325 NZ_CP090732:c1694232-1693831 [Burkholderia cepacia]
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTGGTCCACGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCCATCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTACGCAAGAAG
CTGAGGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTTTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCGGCAT
AG
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTGGTCCACGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCCATCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTACGCAAGAAG
CTGAGGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTTTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|