Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2217445..2218313 | Replicon | chromosome |
| Accession | NZ_CP069069 | ||
| Organism | Mycobacterium tuberculosis strain N1176 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JN144_RS10370 | Protein ID | WP_010886136.1 |
| Coordinates | 2217445..2217822 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | JN144_RS10375 | Protein ID | WP_003409886.1 |
| Coordinates | 2217864..2218313 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN144_RS10320 | 2213234..2213686 | - | 453 | WP_003899095.1 | lipoprotein | - |
| JN144_RS10325 | 2213750..2214151 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JN144_RS10330 | 2214144..2214326 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JN144_RS10335 | 2214440..2214790 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JN144_RS10340 | 2214801..2215703 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JN144_RS10345 | 2215724..2215915 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN144_RS10350 | 2215916..2216212 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN144_RS10355 | 2216452..2216667 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN144_RS10360 | 2216664..2216975 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN144_RS10365 | 2216949..2217470 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN144_RS10370 | 2217445..2217822 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JN144_RS10375 | 2217864..2218313 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| JN144_RS10380 | 2218310..2218855 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN144_RS10385 | 2218744..2219358 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN144_RS10390 | 2219407..2219703 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JN144_RS10395 | 2219700..2219951 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JN144_RS10400 | 2219938..2220432 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN144_RS10405 | 2220592..2220999 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN144_RS10410 | 2221003..2221275 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN144_RS10415 | 2221308..2222528 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T189309 WP_010886136.1 NZ_CP069069:2217445-2217822 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T189309 NZ_CP090727:1272694-1272990 [Burkholderia multivorans]
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT189309 WP_003409886.1 NZ_CP069069:2217864-2218313 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT189309 NZ_CP090727:1272992-1273393 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAATTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAATTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|