189272

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3559110..3559780 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag JN145_RS16865 Protein ID WP_003899954.1
Coordinates 3559110..3559454 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag JN145_RS16870 Protein ID WP_003899955.1
Coordinates 3559451..3559780 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS16830 3554183..3555043 + 861 WP_003416628.1 alpha/beta hydrolase -
JN145_RS16835 3555018..3555533 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
JN145_RS16840 3555549..3555760 + 212 Protein_3325 (R)-hydratase -
JN145_RS16845 3555773..3556066 + 294 WP_003416635.1 hypothetical protein -
JN145_RS16850 3556354..3557643 + 1290 WP_003416640.1 ATP-binding protein -
JN145_RS16855 3557990..3558424 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
JN145_RS16860 3558427..3558879 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN145_RS16865 3559110..3559454 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN145_RS16870 3559451..3559780 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
JN145_RS16875 3560318..3560665 + 348 WP_003899956.1 DUF2384 domain-containing protein -
JN145_RS16880 3560662..3561282 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
JN145_RS16885 3561442..3562707 - 1266 WP_003909837.1 hypothetical protein -
JN145_RS16890 3562875..3563084 + 210 WP_003416778.1 hypothetical protein -
JN145_RS16895 3563331..3564365 - 1035 WP_003416786.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T189272 WP_003899954.1 NZ_CP069068:3559110-3559454 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T189272 NZ_CP090715:c1221570-1221274 [Burkholderia multivorans]
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT189272 WP_003899955.1 NZ_CP069068:3559451-3559780 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT189272 NZ_CP090715:c1221272-1220871 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAATTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References