Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2979892..2980540 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A7U8TVG5
Locus tag JN145_RS14070 Protein ID WP_003909715.1
Coordinates 2979892..2980215 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN145_RS14075 Protein ID WP_003899415.1
Coordinates 2980295..2980540 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS14040 2975215..2976213 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
JN145_RS14045 2976227..2976691 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN145_RS14050 2976679..2976930 + 252 WP_003908028.1 hypothetical protein -
JN145_RS14055 2977101..2978540 - 1440 WP_003901443.1 phage major capsid protein -
JN145_RS14060 2978548..2979081 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN145_RS14065 2979234..2979725 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN145_RS14070 2979892..2980215 - 324 WP_003909715.1 type II toxin-antitoxin system toxin Toxin
JN145_RS14075 2980295..2980540 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN145_RS14080 2980537..2981967 - 1431 WP_202582051.1 DUF3631 domain-containing protein -
JN145_RS14085 2981969..2982361 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN145_RS14090 2982358..2982618 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN145_RS14095 2982635..2982997 - 363 WP_003900543.1 hypothetical protein -
JN145_RS14100 2983000..2984127 - 1128 WP_003899420.1 site-specific integrase -
JN145_RS14105 2984272..2984499 - 228 WP_003909716.1 hypothetical protein -
JN145_RS14110 2984496..2984885 - 390 WP_003899422.1 hypothetical protein -
JN145_RS14115 2984791..2985063 + 273 WP_003900544.1 hypothetical protein -
JN145_RS14120 2985162..2985395 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2975215..2984127 8912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.81 Da        Isoelectric Point: 8.6568

>T189264 WP_003909715.1 NZ_CP069068:c2980215-2979892 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T189264 NZ_CP090708:1821471-1822049 [Burkholderia multivorans]
ATGAACCCTGACACGATCCGCGTACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTAGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACATGCACGAACGCGACGACCTGCTCACGTTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAGCTCGTCGCACTGTGGGACGAATACGACGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGACTAC
GGCCGGCGCTATACGGATGCGGCACCGCTGTTCAGCGCGATCCGCGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACAAACGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189264 WP_003899415.1 NZ_CP069068:c2980540-2980295 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189264 NZ_CP090708:1820779-1821336 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTGGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCACCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTCGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAGATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGATTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCGTCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGATCGGCGGCACGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8TVG5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References