189254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2268488..2269407 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag JN145_RS10690 Protein ID WP_003900449.1
Coordinates 2268802..2269407 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag JN145_RS10685 Protein ID WP_003410124.1
Coordinates 2268488..2268793 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS10655 2263499..2264755 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
JN145_RS10660 2265109..2265684 + 576 WP_003410100.1 hypothetical protein -
JN145_RS10665 2265681..2266721 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
JN145_RS10670 2266963..2267682 + 720 WP_003410108.1 DUF433 domain-containing protein -
JN145_RS10675 2267672..2268088 + 417 WP_003410114.1 hypothetical protein -
JN145_RS10680 2268104..2268403 - 300 WP_003410120.1 hypothetical protein -
JN145_RS10685 2268488..2268793 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
JN145_RS10690 2268802..2269407 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN145_RS10695 2269432..2269791 - 360 WP_003410131.1 hypothetical protein -
JN145_RS10700 2269951..2270604 - 654 WP_014324107.1 hypothetical protein -
JN145_RS10705 2270580..2270816 - 237 WP_003410133.1 hypothetical protein -
JN145_RS10710 2271023..2271919 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T189254 WP_003900449.1 NZ_CP069068:c2269407-2268802 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T189254 NZ_CP090706:c83415-83008 [Burkholderia multivorans]
ATGAGCCTCTATCTGCTCGACACCAATATTTTGTCGAACGTAATCCGGGACCCTCGGGGCGCGTGCGCTTCGCGCATCGG
GGAAACGCCGCCCGAGCAAGTGTGCACCTCGATCGTCGTCGCGGCCGAGCTACGGTACGGCGTCTGTAAGCGCGGCTCCT
CGGCGCTCGCGCAGCGTGTCGAGCAGCTGCTCGCGAGCTTGACCGTATTGCCGCTGCAGTCGGACGCGGATCAATGCTAC
GGGCGGCTCCGAGCCGATCTCGAGAGGCAGGGTCAGTTGATCGGGGCGAACGACATGCTGATCGCTGCCCATGCGCTGGC
CGTCGACGCCGTCTTGGTCACGGACAATACGGCCGAATTCACCCGCGTTGCAGGGCTCGCCGTCGAAAACTGGCTGCGGC
CTGCGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT189254 WP_003410124.1 NZ_CP069068:c2268793-2268488 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT189254 NZ_CP090706:c83654-83412 [Burkholderia multivorans]
ATGCCAACCCATGACACCCGCCATGCACGCCTATTTCGCAACGGACGTAGCCAGGCCGTGCGGATCCCGCGCGAGTTCGA
GCTGCCGGTCTCGGAAGTCACTATTCATCGTGAAGGTCGGCGCCTAATCATCGAACCGGTCGAAGCGCCGTCTCTACGCG
AGCTATTCGCGCAATGGGCGCCCTTGGACGAAACTTTCCCTGACATCGAAAACCTCCCGGCTGAACCGGTCGATATTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV30

References