Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2208162..2209030 | Replicon | chromosome |
| Accession | NZ_CP069068 | ||
| Organism | Mycobacterium tuberculosis strain N1272 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JN145_RS10330 | Protein ID | WP_010886136.1 |
| Coordinates | 2208162..2208539 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | JN145_RS10335 | Protein ID | WP_003409886.1 |
| Coordinates | 2208581..2209030 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN145_RS10280 | 2203951..2204403 | - | 453 | WP_003899095.1 | lipoprotein | - |
| JN145_RS10285 | 2204467..2204868 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JN145_RS10290 | 2204861..2205043 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JN145_RS10295 | 2205157..2205507 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JN145_RS10300 | 2205518..2206420 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JN145_RS10305 | 2206441..2206632 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN145_RS10310 | 2206633..2206929 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN145_RS10315 | 2207169..2207384 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN145_RS10320 | 2207381..2207692 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN145_RS10325 | 2207666..2208187 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN145_RS10330 | 2208162..2208539 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JN145_RS10335 | 2208581..2209030 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| JN145_RS10340 | 2209027..2209572 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN145_RS10345 | 2209461..2210075 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN145_RS10350 | 2210124..2210420 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JN145_RS10355 | 2210417..2210668 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JN145_RS10360 | 2210655..2211149 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN145_RS10365 | 2211309..2211716 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN145_RS10370 | 2211720..2211992 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN145_RS10375 | 2212025..2213245 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T189248 WP_010886136.1 NZ_CP069068:2208162-2208539 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T189248 NZ_CP090705:c399850-399533 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT189248 WP_003409886.1 NZ_CP069068:2208581-2209030 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT189248 NZ_CP090705:c399529-399230 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAATATTTCGAAGC
CTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATTCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAATATTTCGAAGC
CTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATTCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|