Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2991329..2991977 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A7U8TVG5
Locus tag JN146_RS14110 Protein ID WP_003909715.1
Coordinates 2991329..2991652 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag JN146_RS14115 Protein ID WP_003899415.1
Coordinates 2991732..2991977 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS14080 2986652..2987650 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
JN146_RS14085 2987664..2988128 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
JN146_RS14090 2988116..2988367 + 252 WP_003908028.1 hypothetical protein -
JN146_RS14095 2988538..2989977 - 1440 WP_003901443.1 phage major capsid protein -
JN146_RS14100 2989985..2990518 - 534 WP_003899412.1 HK97 family phage prohead protease -
JN146_RS14105 2990671..2991162 - 492 WP_003900541.1 phage terminase small subunit P27 family -
JN146_RS14110 2991329..2991652 - 324 WP_003909715.1 type II toxin-antitoxin system toxin Toxin
JN146_RS14115 2991732..2991977 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
JN146_RS14120 2991974..2993401 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
JN146_RS14125 2993403..2993795 - 393 WP_003899417.1 DUF2742 domain-containing protein -
JN146_RS14130 2993792..2994052 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
JN146_RS14135 2994069..2994431 - 363 WP_003900543.1 hypothetical protein -
JN146_RS14140 2994434..2995561 - 1128 WP_003899420.1 site-specific integrase -
JN146_RS14145 2995706..2995933 - 228 WP_003909716.1 hypothetical protein -
JN146_RS14150 2995930..2996319 - 390 WP_003899422.1 hypothetical protein -
JN146_RS14155 2996225..2996497 + 273 WP_003900544.1 hypothetical protein -
JN146_RS14160 2996596..2996829 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2986652..2995561 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.81 Da        Isoelectric Point: 8.6568

>T189203 WP_003909715.1 NZ_CP069067:c2991652-2991329 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T189203 NZ_CP090691:150641-151048 [Burkholderia multivorans]
ATGAGCCTCTATCTGCTCGACACCAATATTTTGTCGAACGTGATCCGAGACCCACGGGGCGCATGCGCTTCGCGCATCGG
GGAAACGCGGCCCGAGCAAGTGTGCACCTCGATCGTCGTCGCGGCCGAGCTACGGTACGGCGTCTGTAAGCGCGGCTCCT
CGGCGCTCGCCCAGCGTGTCGAGCAGCTGCTCGCGAGCTTGACCGTATTACCGCTGCAGTCCGACGCGGATCAGTGCTAC
GGGCGGCTGCGAGCCGATCTCGAGAGGCAGGGTCAGTTGATCGGGGCGAACGACATGCTGATCGCTGCCCACGCGATGGC
CGTCGACGCCGTCTTGGTCACGGACAATACGGCCGAATTCACTCGCGTTACAGGACTCGCCGTCGAAAACTGGCTCCGGC
CTGCGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT189203 WP_003899415.1 NZ_CP069067:c2991977-2991732 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT189203 NZ_CP090691:150402-150644 [Burkholderia multivorans]
ATGCCAACCCATGACACCCGCCACGCACGCCTATTTCGCAACGGACGTAGCCAGGCCGTGCGGATCCCGCGCGAGTTCGA
GCTGCCGGTCTCGGAAGTCACTATTCATCGTGAAGGCCGGCGCCTAATCATCGAACCGGTCGAAGCGCCGTCTCTACGCG
AGCTATTTGCGCAATGGGCGCCCTTGGACGAAACTTTCCCTGACATCGAAAACCTCCCCGCTGAACCGGTCGATATTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8TVG5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References