Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2207039..2207907 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag JN147_RS10255 Protein ID WP_010886136.1
Coordinates 2207039..2207416 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag JN147_RS10260 Protein ID WP_003409886.1
Coordinates 2207458..2207907 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS10205 2202828..2203280 - 453 WP_003910479.1 hypothetical protein -
JN147_RS10210 2203344..2203745 + 402 WP_003409869.1 hypothetical protein -
JN147_RS10215 2203738..2203920 - 183 WP_003409870.1 hypothetical protein -
JN147_RS10220 2204034..2204384 - 351 WP_003910480.1 hypothetical protein -
JN147_RS10225 2204395..2205297 - 903 WP_003409874.1 hypothetical protein -
JN147_RS10230 2205318..2205509 - 192 WP_003409876.1 hypothetical protein -
JN147_RS10235 2205510..2205806 - 297 WP_003409877.1 hypothetical protein -
JN147_RS10240 2206046..2206261 + 216 WP_003409878.1 antitoxin -
JN147_RS10245 2206258..2206569 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN147_RS10250 2206543..2207064 - 522 WP_003904745.1 hypothetical protein -
JN147_RS10255 2207039..2207416 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
JN147_RS10260 2207458..2207907 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JN147_RS10265 2207904..2208449 + 546 WP_003409891.1 SecB-like chaperone -
JN147_RS10270 2208338..2208952 - 615 WP_003910483.1 hypothetical protein -
JN147_RS10275 2209001..2209297 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
JN147_RS10280 2209294..2209545 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
JN147_RS10285 2209532..2210026 + 495 WP_003899099.1 hypothetical protein -
JN147_RS10290 2210186..2210593 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN147_RS10295 2210597..2210869 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN147_RS10300 2210902..2212122 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T189127 WP_010886136.1 NZ_CP069066:2207039-2207416 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T189127 NZ_CP090648:6238455-6239033 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT189127 WP_003409886.1 NZ_CP069066:2207458-2207907 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT189127 NZ_CP090648:6237812-6238366 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References