Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2206742..2207610 | Replicon | chromosome |
| Accession | NZ_CP069064 | ||
| Organism | Mycobacterium tuberculosis strain N1202 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | JN149_RS10250 | Protein ID | WP_010886136.1 |
| Coordinates | 2206742..2207119 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | JN149_RS10255 | Protein ID | WP_003409886.1 |
| Coordinates | 2207161..2207610 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN149_RS10200 | 2202531..2202983 | - | 453 | WP_003899095.1 | lipoprotein | - |
| JN149_RS10205 | 2203047..2203448 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| JN149_RS10210 | 2203441..2203623 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| JN149_RS10215 | 2203737..2204087 | - | 351 | WP_003910480.1 | hypothetical protein | - |
| JN149_RS10220 | 2204098..2205000 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JN149_RS10225 | 2205021..2205212 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN149_RS10230 | 2205213..2205509 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN149_RS10235 | 2205749..2205964 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN149_RS10240 | 2205961..2206272 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN149_RS10245 | 2206246..2206767 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN149_RS10250 | 2206742..2207119 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| JN149_RS10255 | 2207161..2207610 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| JN149_RS10260 | 2207607..2208152 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN149_RS10265 | 2208041..2208655 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN149_RS10270 | 2208704..2209000 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JN149_RS10275 | 2208997..2209248 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| JN149_RS10280 | 2209235..2209729 | + | 495 | WP_244735024.1 | hypothetical protein | - |
| JN149_RS10285 | 2209889..2210296 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN149_RS10290 | 2210300..2210572 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN149_RS10295 | 2210605..2211825 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T189011 WP_010886136.1 NZ_CP069064:2206742-2207119 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T189011 NZ_CP090611:2352344-2352634 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT189011 WP_003409886.1 NZ_CP069064:2207161-2207610 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT189011 NZ_CP090611:2352153-2352344 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|