Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2274177..2275096 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag JN151_RS10655 Protein ID WP_003900449.1
Coordinates 2274491..2275096 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag JN151_RS10650 Protein ID WP_003410124.1
Coordinates 2274177..2274482 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS10620 2269188..2270444 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
JN151_RS10625 2270798..2271373 + 576 WP_003410100.1 hypothetical protein -
JN151_RS10630 2271370..2272410 + 1041 WP_244749300.1 ImmA/IrrE family metallo-endopeptidase -
JN151_RS10635 2272652..2273371 + 720 WP_003410108.1 DUF433 domain-containing protein -
JN151_RS10640 2273361..2273777 + 417 WP_003410114.1 hypothetical protein -
JN151_RS10645 2273793..2274092 - 300 WP_003410120.1 hypothetical protein -
JN151_RS10650 2274177..2274482 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
JN151_RS10655 2274491..2275096 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN151_RS10660 2275121..2275480 - 360 WP_003410131.1 hypothetical protein -
JN151_RS10665 2275640..2276293 - 654 WP_014324107.1 hypothetical protein -
JN151_RS10670 2276269..2276505 - 237 WP_003410133.1 hypothetical protein -
JN151_RS10675 2276712..2277608 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T188899 WP_003900449.1 NZ_CP069062:c2275096-2274491 [Mycobacterium tuberculosis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T188899 NZ_CP090591:1799908-1800228 [Pectobacterium aroidearum]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTGCGTCACCTGTAGCCGTCTGGCAACAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACACCGTTCTGTGAGGAAAATGTCATTCAGGCGCATATCG
ATGCTGGCGTCACGCTGGTCAATGCCGTGAACTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGCTCGCGACGGTTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCTGTTGATATTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAGGCATA
A

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT188899 WP_003410124.1 NZ_CP069062:c2274482-2274177 [Mycobacterium tuberculosis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT188899 NZ_CP090591:1799503-1799838 [Pectobacterium aroidearum]
ATGCCATCATCGGATACCCCGGAGTGGGGATTAAAATGTGCCATCACTCGGCGATTCGGAGCCAGACTGGTGCAGGAAGG
TAACCGTCTGCACTATCTGGCAGACCGGGCCAGCATTGTCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAGCGTT
GTTTCCCTGAGCTAATTGAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGTCAGCAGGGGGGTGTCACG
TTGTATTGTAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTGTTGGCTACGTGTATATTGTTATTTATCCTTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References