Detailed information of TA system TA188834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 65664..66505
• Replicon: plasmid P1
• Accession: NZ_CP069005
• Organism: Sulfitobacter mediterraneus strain SC1-11

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: JNX03_RS18950
• Protein ID: WP_203212333.1
• Coordinates: 65987..66505 (+)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: JNX03_RS18945
• Protein ID: WP_203212332.1
• Coordinates: 65664..65990 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNX03_RS18925	61584..61973	+	390	WP_203212328.1	DUF3768 domain-containing protein	-
JNX03_RS18930	62129..64111	+	1983	WP_203212329.1	ParB/RepB/Spo0J family partition protein	-
JNX03_RS18935	64188..64781	+	594	WP_203212330.1	regulator	-
JNX03_RS18940	64884..65537	+	654	WP_203212331.1	hypothetical protein	-
JNX03_RS18945	65664..65990	+	327	WP_203212332.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
JNX03_RS18950	65987..66505	+	519	WP_203212333.1	type II toxin-antitoxin system YhaV family toxin	Toxin
JNX03_RS18955	66599..66763	+	165	WP_170850626.1	hypothetical protein	-
JNX03_RS18960	66753..66905	+	153	WP_009820264.1	hypothetical protein	-
JNX03_RS18965	67008..71270	+	4263	WP_203212334.1	strawberry notch family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..152756	152756

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (19-155)

Antitoxin

• PrlF antitoxin (9-104)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19361.00 Da
• Isoelectric Point: 9.7477

>T188834 WP_203212333.1 NZ_CP069005:65987-66505 [Sulfitobacter mediterraneus]
MSGDSVPAQAPLVVNGWSIYAHPLFLDQLEGLILEVEARKARDPKTWRKKNPTKRLAAIFKLVTEAIPADPGAAAYRQGS
TLGDHRKHWFRAKFFQQYRLFYRFNSDAKVIVVAWVNDDKTLRAYGSKTDAYATFKGMLEDGNPPDNFDALLKEAAAADK
RFETSLEAAPDR

Nucleotide

• Length: 519 bp

>T188834 NZ_CP090575:1923480-1923668 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11838.30 Da
• Isoelectric Point: 4.3818

>AT188834 WP_203212332.1 NZ_CP069005:65664-65990 [Sulfitobacter mediterraneus]
MTALAQDVSKLTDRYQTTVPAGVRKQLKLGKGDQIRYCTEPSGRVYIEPVRSDEEDPVLGAFLDFVEADIKAHPDRIRAF
DGALHGRLAALVGDVDVDLDGPLSLEDE

Nucleotide

• Length: 327 bp

>AT188834 NZ_CP090575:1923198-1923455 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA