Detailed information of TA system TA188831

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 758218..758801
• Replicon: chromosome
• Accession: NZ_CP068998
• Organism: Sulfitobacter mediterraneus strain SC7-37

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JNX02_RS03685
• Protein ID: WP_203199048.1
• Coordinates: 758520..758801 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JNX02_RS03680
• Protein ID: WP_037907465.1
• Coordinates: 758218..758508 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNX02_RS03660	755264..755536	+	273	WP_025048209.1	hypothetical protein	-
JNX02_RS03665	755718..756350	+	633	WP_203199046.1	hypothetical protein	-
JNX02_RS03670	756433..757644	+	1212	WP_203199047.1	class I SAM-dependent rRNA methyltransferase	-
JNX02_RS03675	757692..758204	+	513	WP_051584100.1	PIN domain-containing protein	-
JNX02_RS03680	758218..758508	-	291	WP_037907465.1	HigA family addiction module antidote protein	Antitoxin
JNX02_RS03685	758520..758801	-	282	WP_203199048.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JNX02_RS03690	758900..759592	-	693	WP_203199049.1	M48 family metalloprotease	-
JNX02_RS03695	759641..760798	-	1158	WP_203199050.1	cytochrome P450	-
JNX02_RS03700	760902..762755	-	1854	WP_203199051.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (16-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-85)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.91 Da
• Isoelectric Point: 10.2074

>T188831 WP_203199048.1 NZ_CP068998:c758801-758520 [Sulfitobacter mediterraneus]
MIGSTRGKLAAQAMKGKFGKGFPSDLVKRTRAILTALDAATLVEDLRFPPGNHLEELKGDRTGQHSVRINQKWRICFVWT
PSGPTDVEIVDYH

Nucleotide

• Length: 282 bp

>T188831 NZ_CP090575:782099-782308 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10561.33 Da
• Isoelectric Point: 8.5285

>AT188831 WP_037907465.1 NZ_CP068998:c758508-758218 [Sulfitobacter mediterraneus]
VSLLENPMHPGEVLRELYLDPLDLGAIALARRLAVPRTRIERLVKGVTNMTPDTALRLARAFGTTPAYWMNLQTNYDMAL
AAKKVDVSSIEPLSAA

Nucleotide

• Length: 291 bp

>AT188831 NZ_CP090575:781799-782092 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA