Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 659141..659841 Replicon chromosome
Accession NZ_CP068985
Organism Nonomuraea coxensis DSM 45129

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Nocox_RS03400 Protein ID WP_020544733.1
Coordinates 659467..659841 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Nocox_RS03395 Protein ID WP_020544734.1
Coordinates 659141..659470 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Nocox_RS03375 (Nocox_03310) 654498..655094 + 597 WP_211212877.1 HAD family phosphatase -
Nocox_RS03380 (Nocox_03315) 655353..656207 - 855 WP_219495500.1 transposase family protein -
Nocox_RS03385 (Nocox_03320) 656569..657405 - 837 WP_157383200.1 transposase family protein -
Nocox_RS03390 658166..658849 + 684 WP_051112635.1 tyrosine-type recombinase/integrase -
Nocox_RS03395 (Nocox_03330) 659141..659470 - 330 WP_020544734.1 helix-turn-helix transcriptional regulator Antitoxin
Nocox_RS03400 (Nocox_03335) 659467..659841 - 375 WP_020544733.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Nocox_RS03405 (Nocox_03340) 660236..660481 - 246 WP_020544732.1 hypothetical protein -
Nocox_RS03410 (Nocox_03345) 660482..660814 - 333 WP_020544731.1 DUF6247 family protein -
Nocox_RS03420 (Nocox_03355) 661120..661695 + 576 WP_026214653.1 dCTP deaminase -
Nocox_RS03425 (Nocox_03360) 661947..662564 + 618 WP_020544729.1 DUF47 family protein -
Nocox_RS03430 (Nocox_03365) 662574..663578 + 1005 WP_020544728.1 inorganic phosphate transporter -
Nocox_RS03435 (Nocox_03370) 663648..664553 - 906 WP_026214652.1 mycothiol synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14200.14 Da        Isoelectric Point: 4.4847

>T188822 WP_020544733.1 NZ_CP068985:c659841-659467 [Nonomuraea coxensis DSM 45129]
MAWDIILLEPVDVWFLKLCESDPDTAALIEQAIDRLAEVGPALGRPLVDTLEHSNLKNLKELRPGSRKRSEIRMLFVFDP
DRAAIFLVAGDKAGQWSRWYDEAVPLAEARYADYRAEQDKETDR

Download         Length: 375 bp

>T188822 NZ_CP090570:2750705-2750812 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12003.56 Da        Isoelectric Point: 7.5248

>AT188822 WP_020544734.1 NZ_CP068985:c659470-659141 [Nonomuraea coxensis DSM 45129]
MSTARRWQDVKAEAHRRHPELAEPERQAKARTELDAYIAGHHLKELRKSTGKTQAEVAQILGVSQSRISQIENGDIEAME
LETLRAYAAALGGHLDITISVGPHSVKVA

Download         Length: 330 bp

>AT188822 NZ_CP090570:c2750658-2750592 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References