Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3827380..3827977 Replicon chromosome
Accession NZ_CP068972
Organism Klebsiella pneumoniae strain fekpn2511

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JN237_RS18710 Protein ID WP_004142563.1
Coordinates 3827660..3827977 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JN237_RS18705 Protein ID WP_004142561.1
Coordinates 3827380..3827667 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN237_RS18675 3823461..3823709 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JN237_RS18680 3823727..3824068 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JN237_RS18685 3824099..3825214 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
JN237_RS18690 3825393..3825974 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JN237_RS18695 3825974..3826342 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JN237_RS18700 3826462..3827115 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JN237_RS18705 3827380..3827667 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JN237_RS18710 3827660..3827977 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN237_RS18715 3828162..3829205 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
JN237_RS18720 3829872..3830738 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
JN237_RS18725 3830847..3832274 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T188800 WP_004142563.1 NZ_CP068972:c3827977-3827660 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T188800 NZ_CP090566:c71160-70759 [Xanthomonas citri pv. malvacearum]
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAAAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTAAGAGCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT188800 WP_004142561.1 NZ_CP068972:c3827667-3827380 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT188800 NZ_CP090566:c71417-71157 [Xanthomonas citri pv. malvacearum]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGCACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References