Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 326759..327345 Replicon chromosome
Accession NZ_CP068972
Organism Klebsiella pneumoniae strain fekpn2511

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag JN237_RS01530 Protein ID WP_002920800.1
Coordinates 326977..327345 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag JN237_RS01525 Protein ID WP_004174006.1
Coordinates 326759..326980 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN237_RS01505 322916..323842 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JN237_RS01510 323839..325116 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
JN237_RS01515 325113..325880 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JN237_RS01520 325882..326595 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JN237_RS01525 326759..326980 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN237_RS01530 326977..327345 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JN237_RS01535 327618..328934 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JN237_RS01540 329041..329928 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JN237_RS01545 329925..330770 + 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JN237_RS01550 330772..331842 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 323839..332579 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T188788 WP_002920800.1 NZ_CP068972:326977-327345 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T188788 NZ_CP090561:2267527-2267778 [Xanthomonas citri pv. malvacearum]
ATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT188788 WP_004174006.1 NZ_CP068972:326759-326980 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT188788 NZ_CP090561:2267222-2267500 [Xanthomonas citri pv. malvacearum]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References