Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4248102..4248360 Replicon chromosome
Accession NZ_CP068828
Organism Escherichia coli strain RIVM_C030443

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN35_RS20330 Protein ID WP_000809168.1
Coordinates 4248208..4248360 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4248102..4248159 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN35_RS20315 4244494..4245453 + 960 WP_000871674.1 hypothetical protein -
JNN35_RS20320 4245491..4246390 - 900 WP_001300855.1 transcriptional activator NhaR -
JNN35_RS20325 4246456..4247622 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4248102..4248159 - 58 - - Antitoxin
JNN35_RS20330 4248208..4248360 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JNN35_RS20335 4248464..4249594 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN35_RS20340 4249683..4251599 - 1917 WP_000516135.1 molecular chaperone DnaK -
JNN35_RS20345 4251975..4252379 + 405 WP_000843584.1 DUF2541 family protein -
JNN35_RS20350 4252405..4253118 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188725 WP_000809168.1 NZ_CP068828:4248208-4248360 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188725 NZ_CP090541:2109940-2110043 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT188725 NZ_CP068828:c4248159-4248102 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References