Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4114782..4115475 Replicon chromosome
Accession NZ_CP068825
Organism Escherichia coli strain RIVM_C030256

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JNN79_RS19735 Protein ID WP_000415584.1
Coordinates 4115179..4115475 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JNN79_RS19730 Protein ID WP_000650107.1
Coordinates 4114782..4115177 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN79_RS19720 4110646..4112904 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JNN79_RS19725 4113042..4114649 - 1608 WP_001735743.1 ABC transporter substrate-binding protein -
JNN79_RS19730 4114782..4115177 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JNN79_RS19735 4115179..4115475 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JNN79_RS19740 4115680..4116162 - 483 WP_000183505.1 transcriptional regulator -
JNN79_RS19745 4116215..4116607 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JNN79_RS19750 4116759..4117418 + 660 WP_001221510.1 two-component system response regulator QseB -
JNN79_RS19755 4117415..4118764 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
JNN79_RS19760 4118810..4119142 - 333 WP_000917684.1 DUF2645 family protein -
JNN79_RS19765 4119461..4120042 + 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
JNN79_RS19770 4120073..4120387 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T188634 WP_000415584.1 NZ_CP068825:c4115475-4115179 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T188634 NZ_CP090518:1315576-1315857 [Xylella fastidiosa subsp. fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT188634 WP_000650107.1 NZ_CP068825:c4115177-4114782 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT188634 NZ_CP090518:1315326-1315589 [Xylella fastidiosa subsp. fastidiosa]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTGCTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGTATGATGCTGACCCGCATTGCCCGCGAGAAGGCGCTGCCGTTCGAGCCGCTGGTGC
CGAACGAAACTACCATCGCAGCCATGCGTGAAGCCCGTGCTGGTCACCTCAAGAGCTTTGATAGTATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References