Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 638432..638690 Replicon chromosome
Accession NZ_CP068825
Organism Escherichia coli strain RIVM_C030256

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN79_RS03025 Protein ID WP_000809168.1
Coordinates 638432..638584 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 638633..638690 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN79_RS03005 633674..634387 - 714 WP_001102367.1 acidic protein MsyB -
JNN79_RS03010 634413..634817 - 405 WP_000843584.1 DUF2541 family protein -
JNN79_RS03015 635193..637109 + 1917 WP_000516135.1 molecular chaperone DnaK -
JNN79_RS03020 637198..638328 + 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN79_RS03025 638432..638584 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 638633..638690 + 58 - - Antitoxin
JNN79_RS03030 639170..640336 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
JNN79_RS03035 640402..641301 + 900 WP_001300855.1 transcriptional activator NhaR -
JNN79_RS03040 641339..642298 - 960 WP_000871674.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188612 WP_000809168.1 NZ_CP068825:c638584-638432 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188612 NZ_CP090513:1222388-1222669 [Xylella fastidiosa subsp. multiplex]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTTGTGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCGCTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin


Download         Length: 58 bp

>AT188612 NZ_CP068825:638633-638690 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References