Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4243036..4243294 Replicon chromosome
Accession NZ_CP068822
Organism Escherichia coli strain RIVM_C029324

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN44_RS20260 Protein ID WP_000809168.1
Coordinates 4243142..4243294 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4243036..4243093 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN44_RS20245 4238865..4240124 - 1260 WP_000494927.1 hypothetical protein -
JNN44_RS20250 4240253..4241746 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
JNN44_RS20255 4241766..4242527 - 762 WP_001274828.1 hypothetical protein -
- 4243036..4243093 - 58 - - Antitoxin
JNN44_RS20260 4243142..4243294 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JNN44_RS20265 4243399..4244529 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN44_RS20270 4244618..4246534 - 1917 WP_000516135.1 molecular chaperone DnaK -
JNN44_RS20275 4246906..4247310 + 405 WP_000843689.1 DUF2541 family protein -
JNN44_RS20280 4247336..4248049 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188539 WP_000809168.1 NZ_CP068822:4243142-4243294 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188539 NZ_CP090504:1772417-1772698 [Xylella fastidiosa subsp. morus]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTTTTCCTTGTGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin


Download         Length: 58 bp

>AT188539 NZ_CP068822:c4243093-4243036 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References