Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1201555..1202282 | Replicon | chromosome |
Accession | NZ_CP068821 | ||
Organism | Escherichia coli strain RIVM_C029952 |
Toxin (Protein)
Gene name | higB | Uniprot ID | V0YLE2 |
Locus tag | JNN43_RS05785 | Protein ID | WP_000547555.1 |
Coordinates | 1201555..1201866 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | JNN43_RS05790 | Protein ID | WP_000126294.1 |
Coordinates | 1201863..1202282 (+) | Length | 140 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JNN43_RS05760 | 1197490..1199199 | + | 1710 | WP_001288122.1 | formate hydrogenlyase subunit HycE | - |
JNN43_RS05765 | 1199209..1199751 | + | 543 | WP_000493785.1 | formate hydrogenlyase subunit HycF | - |
JNN43_RS05770 | 1199751..1200518 | + | 768 | WP_000067399.1 | formate hydrogenlyase subunit HycG | - |
JNN43_RS05775 | 1200515..1200925 | + | 411 | WP_001291918.1 | formate hydrogenlyase assembly protein HycH | - |
JNN43_RS05780 | 1200918..1201388 | + | 471 | WP_001551542.1 | hydrogenase maturation peptidase HycI | - |
JNN43_RS05785 | 1201555..1201866 | + | 312 | WP_000547555.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
JNN43_RS05790 | 1201863..1202282 | + | 420 | WP_000126294.1 | helix-turn-helix domain-containing protein | Antitoxin |
JNN43_RS05795 | 1202361..1203785 | - | 1425 | WP_000110355.1 | 6-phospho-beta-glucosidase AscB | - |
JNN43_RS05800 | 1203794..1205251 | - | 1458 | WP_001107889.1 | PTS cellobiose/arbutin/salicin transporter subunit IIBC | - |
JNN43_RS05805 | 1205511..1206521 | + | 1011 | WP_029130985.1 | DNA-binding transcriptional regulator AscG | - |
JNN43_RS05810 | 1206670..1207197 | + | 528 | WP_001078777.1 | electron transport protein HydN | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12439.18 Da Isoelectric Point: 9.5146
>T188483 WP_000547555.1 NZ_CP068821:1201555-1201866 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
Download Length: 312 bp
>T188483 NZ_CP090468:1994590-1994692 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 140 a.a. Molecular weight: 15416.42 Da Isoelectric Point: 4.4596
>AT188483 WP_000126294.1 NZ_CP068821:1201863-1202282 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT188483 NZ_CP090468:c1994699-1994554 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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