Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4216694..4216952 Replicon chromosome
Accession NZ_CP068816
Organism Escherichia coli strain RIVM_C028724

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN36_RS20140 Protein ID WP_000809168.1
Coordinates 4216800..4216952 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4216694..4216751 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN36_RS20125 4212523..4213782 - 1260 WP_000494927.1 hypothetical protein -
JNN36_RS20130 4213911..4215404 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
JNN36_RS20135 4215424..4216185 - 762 WP_001274828.1 hypothetical protein -
- 4216694..4216751 - 58 - - Antitoxin
JNN36_RS20140 4216800..4216952 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JNN36_RS20145 4217057..4218187 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN36_RS20150 4218276..4220192 - 1917 WP_000516135.1 molecular chaperone DnaK -
JNN36_RS20155 4220564..4220968 + 405 WP_000843689.1 DUF2541 family protein -
JNN36_RS20160 4220994..4221707 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188345 WP_000809168.1 NZ_CP068816:4216800-4216952 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188345 NZ_CP090402:c2451455-2451279 [Shigella sp. PIB]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 58 bp

>AT188345 NZ_CP068816:c4216751-4216694 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References