Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4243798..4244056 Replicon chromosome
Accession NZ_CP068815
Organism Escherichia coli strain RIVM_C028620

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN49_RS20260 Protein ID WP_000809168.1
Coordinates 4243904..4244056 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4243798..4243855 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN49_RS20245 4239627..4240886 - 1260 WP_000494927.1 hypothetical protein -
JNN49_RS20250 4241015..4242508 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
JNN49_RS20255 4242528..4243289 - 762 WP_001274828.1 hypothetical protein -
- 4243798..4243855 - 58 - - Antitoxin
JNN49_RS20260 4243904..4244056 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JNN49_RS20265 4244161..4245291 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN49_RS20270 4245380..4247296 - 1917 WP_000516135.1 molecular chaperone DnaK -
JNN49_RS20275 4247668..4248072 + 405 WP_000843689.1 DUF2541 family protein -
JNN49_RS20280 4248098..4248811 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188311 WP_000809168.1 NZ_CP068815:4243904-4244056 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188311 NZ_CP090398:2040729-2040831 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT188311 NZ_CP068815:c4243855-4243798 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References