Detailed information of TA system TA188286

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 188663..188885
• Replicon: chromosome
• Accession: NZ_CP068815
• Organism: Escherichia coli strain RIVM_C028620

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: JNN49_RS00880
• Protein ID: WP_001295224.1
• Coordinates: 188778..188885 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	188663..188729 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN49_RS00860	184104..185006	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
JNN49_RS00865	185017..186000	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
JNN49_RS00870	185997..187001	+	1005	WP_000103577.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JNN49_RS00875	187031..188302	-	1272	WP_001298005.1	amino acid permease	-
-	188663..188729	-	67	-	-	Antitoxin
JNN49_RS00880	188778..188885	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
JNN49_RS00885	188972..190651	-	1680	WP_000191565.1	cellulose biosynthesis protein BcsG	-
JNN49_RS00890	190648..190839	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JNN49_RS00895	190836..192407	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
JNN49_RS00900	192680..192868	+	189	WP_001063314.1	YhjR family protein	-
JNN49_RS00905	192880..193632	+	753	WP_000279536.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T188286 WP_001295224.1 NZ_CP068815:188778-188885 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T188286 NZ_CP090393:c3852266-3851949 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT188286 NZ_CP068815:c188729-188663 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin