188205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 907755..908257 Replicon chromosome
Accession NZ_CP068812
Organism Escherichia coli strain RIVM_C029020

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JNN61_RS04450 Protein ID WP_000767829.1
Coordinates 907755..908009 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JNN61_RS04455 Protein ID WP_001259255.1
Coordinates 908006..908257 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN61_RS04420 902770..902997 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
JNN61_RS04425 903011..904069 - 1059 WP_023910197.1 transport protein YeeE -
JNN61_RS04430 904248..905606 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JNN61_RS04435 905596..905658 - 63 WP_010723108.1 membrane protein YoeI -
JNN61_RS04440 905873..906802 - 930 WP_000803351.1 LysR family transcriptional regulator -
JNN61_RS04445 906848..907672 - 825 WP_202849972.1 SDR family oxidoreductase -
JNN61_RS04450 907755..908009 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JNN61_RS04455 908006..908257 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JNN61_RS04460 908540..908590 + 51 WP_001364200.1 his operon leader peptide -
JNN61_RS04465 908736..909635 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
JNN61_RS04470 909641..910945 + 1305 WP_001559366.1 histidinol dehydrogenase -
JNN61_RS04475 910942..912012 + 1071 WP_000108970.1 histidinol-phosphate transaminase -
JNN61_RS04480 912012..913079 + 1068 WP_001563933.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T188205 WP_000767829.1 NZ_CP068812:c908009-907755 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T188205 NZ_CP090355:c2294378-2294064 [Pseudomonas kribbensis]
ATGATTTTTATTGAGACTCGGATCTTTACCCGTCGAGTAAAAGAGCTGCTGGACGATGACACTTACGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCTTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGAAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTGATCTACTACCACTTCGTTTCGGCGTCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGTAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT188205 WP_001259255.1 NZ_CP068812:c908257-908006 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT188205 NZ_CP090355:c2294061-2293774 [Pseudomonas kribbensis]
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGTGTGCAAGAGATGGACGAGATTGTACGAGGCCAGCGCGCACCTTCTCG
CGAATTCCACGTTGATGCTTTGCAGGTCAAAGAGATTCGTAAAGCTACCGGTTTGACCCAGGCCAAATTTGCGGCACTGA
TCGACGTCCAGCTCGGCACTCTACGAAATTGGGAACAGGGTCGTCGCGAGCCTACCGGGCCGGCAAAAGCTTTGCTCAAG
GCCATTCATAACGACCCGGTTCATGTTTTGAATGCATTGGCCCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References