Detailed information of TA system TA188123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4340556..4340968
• Replicon: chromosome
• Accession: NZ_CP068809
• Organism: Escherichia coli strain RIVM_C028497

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: JNN39_RS20770
• Protein ID: WP_000132614.1
• Coordinates: 4340627..4340968 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4340556..4340632 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN39_RS20760	4337231..4338700	+	1470	WP_001540814.1	type I restriction-modification system subunit M	-
JNN39_RS20765	4338700..4340406	+	1707	WP_001100194.1	restriction endonuclease subunit S	-
-	4340556..4340632	-	77	NuclAT_6	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_6	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_6	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_6	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_7	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_7	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_7	-	Antitoxin
-	4340556..4340632	-	77	NuclAT_7	-	Antitoxin
JNN39_RS20770	4340627..4340968	+	342	WP_000132614.1	endoribonuclease SymE	Toxin
JNN39_RS20775	4341015..4343108	-	2094	WP_000648237.1	DUF262 domain-containing protein	-
JNN39_RS20780	4343206..4343286	-	81	WP_020233658.1	hypothetical protein	-
JNN39_RS20785	4343514..4344434	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
JNN39_RS20790	4344619..4345899	+	1281	WP_001298033.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	4324435..4343171	18736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T188123 WP_000132614.1 NZ_CP068809:4340627-4340968 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T188123 NZ_CP090304:c3195560-3195162 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT188123 NZ_CP068809:c4340632-4340556 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin