Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4215332..4215590 Replicon chromosome
Accession NZ_CP068809
Organism Escherichia coli strain RIVM_C028497

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag JNN39_RS20110 Protein ID WP_000809168.1
Coordinates 4215438..4215590 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4215332..4215389 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN39_RS20095 4211161..4212420 - 1260 WP_000494927.1 hypothetical protein -
JNN39_RS20100 4212549..4214042 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
JNN39_RS20105 4214062..4214823 - 762 WP_001274828.1 hypothetical protein -
- 4215332..4215389 - 58 - - Antitoxin
JNN39_RS20110 4215438..4215590 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
JNN39_RS20115 4215695..4216825 - 1131 WP_001118464.1 molecular chaperone DnaJ -
JNN39_RS20120 4216914..4218830 - 1917 WP_000516135.1 molecular chaperone DnaK -
JNN39_RS20125 4219202..4219606 + 405 WP_000843689.1 DUF2541 family protein -
JNN39_RS20130 4219632..4220345 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T188121 WP_000809168.1 NZ_CP068809:4215438-4215590 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T188121 NZ_CP090304:c1968153-1968050 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT188121 NZ_CP068809:c4215389-4215332 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References