Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 969498..970000 Replicon chromosome
Accession NZ_CP068807
Organism Escherichia coli strain RIVM_C018583

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JNN51_RS04890 Protein ID WP_000767829.1
Coordinates 969498..969752 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JNN51_RS04895 Protein ID WP_001259255.1
Coordinates 969749..970000 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN51_RS04865 965280..966638 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JNN51_RS04870 966628..966690 - 63 WP_010723108.1 membrane protein YoeI -
JNN51_RS04875 966897..967355 - 459 WP_001550720.1 IS200/IS605 family transposase -
JNN51_RS04880 967616..968545 - 930 WP_000803351.1 LysR family transcriptional regulator -
JNN51_RS04885 968591..969415 - 825 WP_000754749.1 SDR family oxidoreductase -
JNN51_RS04890 969498..969752 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JNN51_RS04895 969749..970000 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JNN51_RS04900 970283..970333 + 51 WP_001364200.1 his operon leader peptide -
JNN51_RS04905 970479..971378 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
JNN51_RS04910 971384..972688 + 1305 WP_001559366.1 histidinol dehydrogenase -
JNN51_RS04915 972685..973755 + 1071 WP_000108970.1 histidinol-phosphate transaminase -
JNN51_RS04920 973755..974822 + 1068 WP_001563933.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 966897..967355 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T188044 WP_000767829.1 NZ_CP068807:c969752-969498 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T188044 NZ_CP090208:c532804-532496 [Pantoea agglomerans]
ATGCACGTTATCTCAAGGGAGCCATTCAGGGAAGCAGCAGAGTTTCCAAACGACGCCACTGCATTGGATGCCATATATCT
GGTGTTAAAAGGCGAAAATTTTAGGTCGCCAGACGCATTAAAAAAGCGATTTCCCAGCCTGGACCGGATGAAATATCGGG
AGAAATGGTGGGTAATTGATGCAGGCGGTAATAACCTGAGGATAATGTTTTTCGTTGATTTTGAGCGAAGCAAAATTTTC
ATCAAGCATATCGTTACGCATCCGGAATACGACAGGCTTATAAAGAAGTATCGGGAGCAGAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT188044 WP_001259255.1 NZ_CP068807:c970000-969749 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT188044 NZ_CP090208:c532499-532080 [Pantoea agglomerans]
ATGATTACCGAAGCTATTCAGGCTACCAACCAACTGATTGAAATTATTCCTTTTTTAGGAGGGAGCACTCAGAAAAAGGA
TTATGAACAGGCACTGGAATTGGTGGAGTATCTGGTAGAGCATCAACCTGATAGCCCGCTAATTGATATGCTGGCTGATA
AAGTGGCCCGTTACGAAGATAATGCACCTGAATTCGCTGAGTTTAACGCCCGCATTGCAAAAATGCCGCAGGGCGTTGCG
TTACTGCGAGTACTGATGGATCAGTATGGCCTTAATCAATCCTCGTTTACTGAAGAAATTGGCCAGCGCTCTTACGTGAG
CCGTATTCTGCGTGGTCAACGATCCTTAACGGATAAACATAAAGCGCGTCTGGCAGCGCGGTTTAATCTGCCGTTCGAAG
CCTTTAATGGCAAGGCGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References