Detailed information of TA system TA187941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 737477..738170
• Replicon: chromosome
• Accession: NZ_CP068804
• Organism: Escherichia coli strain RIVM_C018563

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: JNN37_RS03505
• Protein ID: WP_000415583.1
• Coordinates: 737477..737773 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: JNN37_RS03510
• Protein ID: WP_000650107.1
• Coordinates: 737775..738170 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN37_RS03470	732565..732879	-	315	WP_000958598.1	antibiotic biosynthesis monooxygenase	-
JNN37_RS03475	732910..733491	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
JNN37_RS03480	733810..734142	+	333	WP_000917684.1	DUF2645 family protein	-
JNN37_RS03485	734188..735537	-	1350	WP_000673402.1	two-component system sensor histidine kinase QseC	-
JNN37_RS03490	735534..736193	-	660	WP_106106579.1	two-component system response regulator QseB	-
JNN37_RS03495	736345..736737	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
JNN37_RS03500	736790..737272	+	483	WP_106106578.1	GyrI-like domain-containing protein	-
JNN37_RS03505	737477..737773	+	297	WP_000415583.1	type II toxin-antitoxin system toxin MqsR	Toxin
JNN37_RS03510	737775..738170	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
JNN37_RS03515	738303..739910	+	1608	WP_106106577.1	ABC transporter substrate-binding protein	-
JNN37_RS03520	740048..742306	+	2259	WP_001281881.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11216.99 Da
• Isoelectric Point: 8.9070

>T187941 WP_000415583.1 NZ_CP068804:737477-737773 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T187941 NZ_CP090137:c1008577-1008050 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGGGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT187941 WP_000650107.1 NZ_CP068804:737775-738170 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT187941 NZ_CP090137:c1008864-1008574 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• PDB: 3HI2
• PDB: 3GA8
• PDB: 3O9X
• PDB: 2KZ8
• PDB: 3FMY
• PDB: 3GN5
• AlphaFold DB: A0A7U9LU65