Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3829978..3830777 Replicon chromosome
Accession NZ_CP068802
Organism Escherichia coli strain RIVM_C018249

Toxin (Protein)


Gene name yhaV Uniprot ID A0A7B2BI69
Locus tag JNN40_RS18320 Protein ID WP_000347258.1
Coordinates 3829978..3830442 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A368IY36
Locus tag JNN40_RS18325 Protein ID WP_001604880.1
Coordinates 3830442..3830777 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN40_RS18290 3824979..3825413 - 435 WP_000948829.1 PTS sugar transporter subunit IIA -
JNN40_RS18295 3825431..3826309 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JNN40_RS18300 3826299..3827078 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JNN40_RS18305 3827089..3827562 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JNN40_RS18310 3827585..3828865 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
JNN40_RS18315 3829114..3829923 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
JNN40_RS18320 3829978..3830442 - 465 WP_000347258.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JNN40_RS18325 3830442..3830777 - 336 WP_001604880.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JNN40_RS18330 3830926..3832497 - 1572 WP_001273737.1 galactarate dehydratase -
JNN40_RS18335 3832872..3834206 + 1335 WP_000599654.1 galactarate/glucarate/glycerate transporter GarP -
JNN40_RS18340 3834222..3834992 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.32 Da        Isoelectric Point: 9.6924

>T187912 WP_000347258.1 NZ_CP068802:c3830442-3829978 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEILKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH

Download         Length: 465 bp

>T187912 NZ_CP090126:840657-841067 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12340.91 Da        Isoelectric Point: 4.8616

>AT187912 WP_001604880.1 NZ_CP068802:c3830777-3830442 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGLDVNIDDEIGDDE

Download         Length: 336 bp

>AT187912 NZ_CP090126:840410-840676 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7B2BI69

Antitoxin

Source ID Structure
AlphaFold DB A0A368IY36

References