Detailed information of TA system TA187905

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2386586..2386844
• Replicon: chromosome
• Accession: NZ_CP068802
• Organism: Escherichia coli strain RIVM_C018249

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JNN40_RS11500
• Protein ID: WP_000809168.1
• Coordinates: 2386692..2386844 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2386586..2386643 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN40_RS11485	2382978..2383937	+	960	WP_000871682.1	hypothetical protein	-
JNN40_RS11490	2383975..2384874	-	900	WP_001300855.1	transcriptional activator NhaR	-
JNN40_RS11495	2384940..2386106	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	2386586..2386643	-	58	-	-	Antitoxin
JNN40_RS11500	2386692..2386844	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JNN40_RS11505	2386948..2388078	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
JNN40_RS11510	2388167..2390083	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JNN40_RS11515	2390459..2390863	+	405	WP_000843579.1	DUF2541 family protein	-
JNN40_RS11520	2390889..2391602	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T187905 WP_000809168.1 NZ_CP068802:2386692-2386844 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T187905 NZ_CP090103:c424376-423963 [Rhizobium leguminosarum]
ATGATCCTGTTGGACACCAACGTGATATCGGAGCCGTGTAAACCGATTCCTGACGGAGCAGTGGTCGCTTGGTTGGATGC
CCAAGCCATCGAAACTCTCTTCGTTTCCGCAATAACAATTGCTGAACTACGTTTTGCGATCGCTGCCATGCCCGCAGGCA
AACGGCAAACTATCCTTCGCGATCGCCTGGAGGAAGAAGTGCTTCCGCATTTTGCCGAACGCATCCTGCCTTTCGATCTT
GCCGCCAGCCAATTTTACTCGGAACTGATGGCGCGCGCTCGAGTATCCGGGAAAGGATCAGCAAGGGGACATATCGCAGC
CACCGCCGTAGCGAACGGCCTTGCCGTCGCAACTCGCGACACAGGCCCTTTTGAGGCCGTTGGGTTGAAAGTGATTAACC
CCTGGCTCCCATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT187905 NZ_CP068802:c2386643-2386586 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin